該基因編碼神經營養性酪氨酸受體激酶(NTRK)家族的一個成員。這種激酶是一種膜結合受體,通過神經營養素結合,磷酸化自身和MAPK途徑的成員。通過這種激酶的信號傳導導致細胞分化,并可能在感知身體位置的本體感受神經元的發育中起到作用。這種基因的突變與髓母細胞瘤、分泌性乳腺癌和其他癌癥有關。一些轉錄變體編碼不同的亞型已被發現的這個基因。
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene.

基因名:NTRK3
別名:GP145-TrkC,TRKC,gp145(trkC)
基因ID:4916
Chromosome:
(GRCh37)
15 Start: 88418230 End: 88799999 Strand: -1
信號通路: 細胞增殖 
靶向藥: 克唑替尼  恩曲替尼  拉羅替尼  拉羅替尼  Selitrectinib  PLX7486 
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